Unlock the true power of particles

Game-changing platforms for nanoparticle encapsulation

Born from Dolomite Microfluidics, with 20 years experience in particle technology, and a strong heritage of microfluidics, engineering and nanoparticle expertise, our range of platforms allow you to transfer between discovery, through development to manufacturing using the same process technology.

We have been at the forefront of this rapidly changing science, listening and adapting as our customers’ needs have evolved. We pave the way to particle perfection, helping our customers produce nanoparticles with unrivalled precision, quality, consistency and control, while reducing your development time and cost. Our product is your process.

Nanoparticles are an excellent delivery method for vaccines, drugs, gene therapies and other APIs

Nanoparticles and nanoscale drug delivery systems (for materials such as small molecules, genetic material and other APIs) have become a significant part of the medical industry’s product research and development focus and the demand for nanoparticle-based medicines and therapies has exploded in recent years. The COVID-19 pandemic catapulted mRNA-based therapeutics into the forefront of life science, realizing the benefits of collaborative global efforts for unprecedented drug development.

Accelerate, optimize & control your drug development pipeline

There is a clear need for automated, effective and efficient production of LNPs for screening, optimization and manufacturing. We recognise that rapid product development requires acceleration and parallel task execution, and scalability and automation are key to address both requirements. Microfluidics is central to achieving scalability and quality issues that traditional methods cannot address.

Microfluidics controls particle size, achieves excellent monodispersity and encapsulation efficiency. Particle integrity is preserved and damage caused by mechanical forces is avoided. Particle Works has developed 4 core platforms to meet the various demands of the drug discovery journey, and using our reusable microfluidics chips ensures that our process technology is scalable across the whole of your drug development pipeline.

Empowering scientists through the drug development pipeline with our pioneering technology

Using the same microfluidic chips and pumping technology at every stage of nanoparticle development ensures your formulations are transferrable and scalable right through from discovery, through development to scale-up and manufacturing.

We are on a journey together. From our game-changing screening platform ALiS – the first to bring automation and high-throughput screening to the marketplace; to the ANP System – a unique, comprehensive and flexible single system for both process optimization and continuous production; to Pilot – our scale-up system; our innovative, pioneering technologies offer the complete solution for our customers’ drug development pipeline.

From discovery to scale-up, we pave the way to particle perfection

ALiS

A NEW game-changing screening platform – the first to bring automation and high-throughput screening to the marketplace.

The Automated Library Synthesis (ALiS) System enables automation and high-throughput screening of LNP formulations and mRNA candidates in early-stage development. The platform delivers excellent monodispersity and encapsulation efficiency, enabling upto 96 experiments within 6 hours.

ANP System

A unique, comprehensive and flexible single system for both process optimization and continuous production.

The Automated Nanoparticle (ANP) System enables automation of process development and initial production of larger samples of LNPs with a select number of promising formulations, tailored to the user’s individual needs for flexible multi-sample and multi-protocol capability.

ANP Pilot

ANP Pilot is the version of the ANP System that will be suitable for GMP environments. Perfect for users conducting final process development in a manufacturing environment, and for initial manufacture for clinical trials/low volume applications. Allowing continuous sample manufacturing, with a 57 liters throughput in 24h (15 g of LNPs, 1.5M Vaccine Doses), it has a direct translation from discovery to development and is scalable by running systems in parallel.

Titan

Our highest throughput platform, Titan, is the final step in your particle production journey, making high volume manufacture in GMP facilities a breeze. Allowing continuous manufacturing of 1,440 l in 24h (~400 g of LNPs, 40M Vaccine Doses), its modular structure enables process flexibility and it is scalable by running systems in parallel.

How our platforms can revolutionize your work

Flexibility

Scalability

Cost saving

Speed

Automation

Precision

Monodispersity

High-throughput

Improved efficiency

See our platforms in action

Would you like to see how our technology can help you with your drug development pipeline?

We would love to show you in person. Simply click on the button below to arrange a demonstration with one of our scientists and we will be in touch very soon!

Get inspired by people like you

Dr Julia Rashba-Step

Dr Julia Rashba-Step

VP of R&D and Alliance Management, Phosphorex

The ANP System offers the best solution for nanoparticle formulation and process optimization providing robust, reproducible results and enabling us to deliver complex projects.  We have complete faith in Particle Works’ capabilities.

Kevin Land

Kevin Land

Mologic, Centre for Advanced Rapid Diagnostics

Using Particle Works technology to create precisely manufactured nanoparticles, coupled with their novel microfluidic technology and ability to scale up production, has been essential in Mologic’s development of ground-breaking diagnostic products.
Bowen Tian

Bowen Tian

Senior Application Specialist, Particle Works

I joined Particle Works because I believe it’s going to make a huge impact on the most challenging and greatly unmet need for LNP gene formulation design, screening and manufacturing towards accelerated clinical applications.

Seeing is believing! Let us prove it.

Are you struggling to imagine what is achievable for your materials on our platforms? Do you want a clearer and more representative indication of how your experiments can be run on our platforms to get the best results? Whether you’ve tried microfluidics before or want to move from a batch to a flow protocol, our proof of principle studies will provide peace of mind and de-risk your purchase. We collaborate closely with you when offering this premium service, quickly testing your materials on our site.

Be part of our journey by exploring particles at events

SLAS 2023

25th February – 1st March 2023

SLAS

San Diego, USA

15th – 16th March 2023

RNA Leaders Europe Congress

Basel, Switzerland

17th – 19th April 2023

2nd Annual LNP Formulation & Process Development Summit

Boston, USA