Nanoparticle-based contrast agents are a rapidly growing and increasingly valuable tool for enhancing medical diagnostics for a wide range of bio imaging modalities.
Nanoparticle surfaces can be conjugated with targeting species such as antibodies, aptamers, peptides etc., giving particles the ability to self-assemble at malignant sites. This enables nanoparticle-based imaging probes to be substantially more specific than the conventional (molecular based) contrast agents.
Other benefits include:
Precision control over nanoparticle size, shape and architecture is particularly important in the context of medical diagnostics for two major reasons:
Typically, nanoparticle suppliers provide non-uniform or polydisperse (CV values >20%) materials with varying particle sizes, shapes and architectures. The material properties vary (e.g. produce a range of emission frequencies) in non-uniform or polydisperse materials, resulting in substantially diminished targeting and contrast ability.
Particle Works offers a range of highly monodisperse (CV values <10%) nanoparticles for applications in bio imaging. These performance materials bring benefits such as:
|Gold Nanoparticles||For light scattering contrast agents we recommend PEG functionalized Gold nanoparticles|
|Quantum dots||When processing in organic solvents, we recommend CdSe quantum dots in toluene|
|When processing in aqueous solvents, we recommend mercaptosuccinic acid functionalized CdSe quantum dots (available on request only)|
|Magnetic nanoparticles||For magnetic contrast agents, we recommend PEG functionalized Oxidatively Stable Cobalt Nanoparticles (available on request only)|