Lateral flow assays (immunochromatographic assays) are simple and well-established diagnostic tests intended for point-of-care and laboratory use. The test detects target molecules (e.g. antigens) by displaying a visual indication (most commonly a colored line) on a test pad.
The test is performed as follows:
Control over the size, shape and architecture of the underlying particles is important in lateral flow assays. It determines the coating efficiency of the particles with antibodies, ease of flow through the test pad as well as the color and intensity of the test lines.
Typically, nanoparticle suppliers provide non-uniform or polydisperse (CV values >20%) material with particles varying in size, shape and architecture. This significantly diminishes the performance of the particles.
Particle Works offers a range of highly monodisperse (CV values <10%) nanoparticles for applications in lateral flow tests. These high-performance materials bring benefits such as:
The following nanoparticles in the Particle Works range are suitable for applications in development of lateral flow assays:
|Gold Nanoparticles||We recommend our range of PEG functionalized Gold nanoparticles for development of lateral flow tests|
|Quantum dots||We recommend mercaptosuccinic acid functionalized CdSe for development of lateral flow tests (available on request).|
|Magnetic nanoparticles||We recommend PEG functionalized oxidatively stable cobalt nanoparticles for the development of magnetic-immunoassays|