Targeted drug delivery is a rapidly developing field within pharmacology. This application involves Active Pharmaceutical Ingredient (API) encapsulation or tethering to nano- or microparticles in order to deliver therapeutic molecules to the malignant site.
This is usually undertaken using one of the two targeting mechanisms:
Precision control over particle size, shape and architecture is extremely important in both cases. These critical parameters determine blood pool residence time, targeting efficacy, distribution of APIs among particles, and the ability to control the lifetime of the particles within the living system.
Typically, nanoparticle suppliers provide non-uniform or polydisperse (CV values >20%) material with various particle sizes, shapes and architectures. The targeting efficacy of such materials is substantially diminished.
Particle Works offers a range of highly monodisperse (CV values <10%) nanoparticles for applications in targeted drug delivery. These high-performance materials bring benefits such as:
|Gold Nanoparticles||We recommend PEG functionalized Gold nanoparticles for further API and antibody functionalization|
|PLGA Beads||We offer customer-specific projects using PLGA, please contact us for further details|
|Magnetic nanoparticles||We recommend PEG functionalized Co-Fe3O4 particles for application in targeted drug delivery (available on request only)|