Our high-performance metal nanoparticles, quantum dots and hydrogel beads are produced using automated, continuous flow processing and droplet microfluidic technologies. These state-of-the-art techniques enable us to supply highly monodisperse and batch-to-batch consistent particles (CV values as low as 1% and 0.5% respectively).
Nano- and microparticles are research tools used by scientists in fields such as biomedicine, diagnostics, industrial catalysis, and many others. These materials possess unique and powerful properties that enable them to emit and scatter light, heat up their immediate surroundings, accelerate chemical reactions, and produce magnetic and acoustic contrast. The unique properties of these materials, and consequently their performance in target applications, are fundamentally determined by the size, shape and architecture of the underlying particles.
However, the materials used by most researchers today are polydisperse (consisting of non-uniform particles). This leads to dilution of the material’s desired performance, such as the broadening of emission lines, and thus a fall in signal-to-noise ratios for contrast agents. Perhaps even more importantly, the use of polydisperse materials leads to inconsistency of experimental results and observations, such as commonly reported inconsistencies of API release profiles in targeted drug delivery applications.
At Particle Works, our goal is to provide the best possible research tools to advance the frontiers of current research. In order to address these challenges, we use state-of-the-art continuous flow and droplet microfluidic technologies as well as automated batch processing. This enables us to design, develop and supply highly monodisperse and batch-to-batch consistent (CV values as low as 1% and 0.5% respectively) nanoparticles and microparticles. These materials enable our customers to benefit from a substantially improved material performance and to generate consistent, reliable data during research and development.
Images of particles fabricated by Particle Works with precision control over size, shape and architecture
The state-of-the-art materials used in research are complex and comprise of a core, a functional coating, and, in most cases, a solvent system. In order to be able to work effectively with these materials, researchers must know the composition and the concentration of the materials used. They also need to be able to share the data.
That is why Particle Works provides comprehensive characterization data with every sample shipped. Our customers are able to download raw characterization data, such as TEM images, absorbance and fluorescence data and particle counts. We permit fair use of this data.
Here are some examples of characterization data we provide (raw and processed):
Examples of characterization data provided by Particle Works: Particle size distribution, TEM image and fluorescence spectra of CdSe quantum dots
Product development after the R&D phase requires a substantial increase in the quantity of the material used. The conventional batch chemical synthesis methods used in nanoparticle fabrication however have significant limitations: poor mass transfer and heat transfer coefficients, inability to control residence time, inability to undertake reactions in a reproducible manner.
This results in a substantial decrease in product quality (increase in CV numbers) when trying to scale up.
Particle Works uses state-of-the-art continuous flow and droplet microfluidic technologies as well as automated batch processing for micro-and nanomaterial production. These technologies are scalable and enable us to maintain the product quality at the output levels from 1ml – 1000L per day for nanoparticle synthesis, and up to 40L per day for microparticle synthesis. This makes Particle Works an ideal supplier of high-performance materials for large-scale applications.
Examples of equipment used by Particle Works at various production scales.